ea0014p605 | (1) | ECE2007
Gueorguiev M
, Lolli F
, Chapple JP
, Quinton R
, Ribeiro-de-Oliveira A
, Gadelha MR
, Popovic V
, Monson JP
, Wass JAH
, Frohman LA
, Grossman AB
, Korbonits M
Pituitary adenomas are present in ∼25% of autopsy samples, and recent studies have also suggested that clinically important pituitary adenomas are some 5 times more common than previously recognised. Acromegaly is almost always due to a sporadic growth-hormone secreting pituitary adenoma, but familial acromegaly has been reported occasionally. Linkage and loss of heterozygosity studies have shown that it is caused by a tumour suppressor gene located at 11q13; very recent...